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Prmt1 Gene Detail
Summary
  • Symbol
    Prmt1
  • Name
    protein arginine N-methyltransferase 1
  • Synonyms
    6720434D09Rik, Hrmt1l2
  • Feature Type
    protein coding gene
  • IDs
    MGI:107846
    NCBI Gene: 15469
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:44626179-44635844 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 29.07 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    313 from dbSNP Build 142
  • Strain Annotations
    1
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_107846
 protein coding gene Chr7:44625413-44635992 (-)
129S1/SvImJ no annotation
A/J no annotation
AKR/J no annotation
BALB/cJ no annotation
C3H/HeJ no annotation
C57BL/6NJ no annotation
CAROLI/EiJ no annotation
CAST/EiJ no annotation
CBA/J no annotation
DBA/2J no annotation
FVB/NJ no annotation
LP/J no annotation
NOD/ShiLtJ no annotation
NZO/HlLtJ no annotation
PWK/PhJ no annotation
SPRET/EiJ no annotation
WSB/EiJ no annotation



Homology
more
  • Human Ortholog
    PRMT1, protein arginine methyltransferase 1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PRMT1, protein arginine methyltransferase 1
  • Synonyms
    ANM1, HCP1, HRMT1L2, IR1B4
  • Links
    NCBI Gene ID: 3276
    neXtProt AC: NX_Q99873
    UniProt: Q99873

  • Chr Location
    19q13.33; chr19:49675786-49689029 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Prmt1 mouse models

Human Disease Mouse Models
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    46 phenotypes from 5 alleles in 4 genetic backgrounds
    5 phenotypes from multigenic genotypes
    55 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Embryos homozygous for a null mutation die before E6.5 and exhibit abnormal embryonic tissue morphology. Mice homozygous for a conditional allele activated in germ cells exhibit male infertility with azoospermia due to meiosis arrest at the leptotene or zygotene stage.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    103
  • GO References
    21
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    903
  • Tissues
    77
  • cDNA Data
    210
  • Literature Summary
    15
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 15469 NCBI Gene Model | MGI Sequence Detail 9666 C57BL/6J ±  kb
    transcript NR_045521 RefSeq | MGI Sequence Detail 1524 ZRU/MplStud  
    polypeptide Q9JIF0 UniProt | EBI | MGI Sequence Detail 371 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 216
      Genomic 1
      cDNA 210
      Primer pair 4
      Other 1

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGD-MRK-36423, MGI:1924993, MGI:2142221
    References
    more
    • Summaries
      All 122
      Developmental Gene Expression 15
      Diseases 1
      Gene Ontology 21
      Phenotypes 55
    • Earliest
      J:33751 Lin WJ, et al., The mammalian immediate-early TIS21 protein and the leukemia-associated BTG1 protein interact with a protein-arginine N-methyltransferase. J Biol Chem. 1996 Jun 21;271(25):15034-44
    • Latest
      J:346858 Ku B, et al., PRMT1 promotes pancreatic cancer development and resistance to chemotherapy. Cell Rep Med. 2024 Mar 19;5(3):101461
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory